衰老：是对去乙酰化酶的一次颠覆？

Aging: a sirtuin shake-up?

作者信息

Vijg Jan, Maslov Alexander Y, Suh Yousin

机构信息

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

出版信息

Cell. 2008 Nov 28;135(5):797-8. doi: 10.1016/j.cell.2008.11.008.

DOI:10.1016/j.cell.2008.11.008

PMID:19041745

Abstract

The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.

摘要

酵母沉默调节蛋白（Sir2）是一种组蛋白脱乙酰酶，它通过染色质修饰抑制基因组不稳定来调节酵母的复制寿命。在本期中，奥伯多弗等人（2008年）报道，Sir2在哺乳动物中的同源物SIRT1参与了DNA损伤诱导的染色质重组，这促进了哺乳动物细胞中的基因组稳定性。