韩国肥胖儿童中前胃动素Leu72Met多态性
Preproghrelin Leu72Met polymorphism in obese Korean children.
作者信息
Jo Dae-Sun, Kim Se-Lim, Kim Sun-Young, Hwang Pyoung Han, Lee Kee-Hyoung, Lee Dae-Yeol
机构信息
Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.
出版信息
J Pediatr Endocrinol Metab. 2005 Nov;18(11):1083-6. doi: 10.1515/jpem.2005.18.11.1083.
Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.
胃饥饿素是一种新型的肠脑肽，具有促生长、致食欲和促脂肪生成的作用。我们检测了222名肥胖韩国儿童的前胃饥饿素Leu72Met多态性，以确定其是否与肥胖相关。Leu72Met多态性的频率在肥胖韩国儿童中为29.3%，超重儿童中为32.3%，瘦儿童中为32.5%。在Met72携带者和非携带者肥胖儿童之间，未发现BMI、全身脂肪、血清甘油三酯、总胆固醇或低密度脂蛋白胆固醇水平有显著差异。我们的数据表明，前胃饥饿素Leu72Met多态性与儿童肥胖无关。
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