Plech Andrzej, Rykaczewska-Czerwińska Monika, Ryszka Florian, Suszka-Switek Aleksandra, Dolińska Barbara, Konopińska Danuta
Department of Pharmacology, Medical Faculty in Zabrze, Medical University of Silesia, H. Jordana 38, PL 41-808 Zabrze, Poland.
Acta Pol Pharm. 2005 Sep-Oct;62(5):393-7.
The brain and internal organs distribution of 125I-labeled [2-8]-leucopyrokinin ([2-8]-LPK), a truncated analog of leucopyrokinin (LPK), an insect myotropic peptide injected into the lateral brain ventricle was determined in rats. A high accumulation of this analog in adrenals and in the hypothalamus and hippocampus of the brain was found. A lesser but significant [2-8]-LPK accumulation in other internal organs and parts of the brain was also observed. The results of the present study confirm results of our previous study performed on the distribution of labeled native LPK in rats. A possible significance of obtained results for the brain function was discussed.
在大鼠中测定了注射到侧脑室的[2-8]-亮氨酸焦激肽（[2-8]-LPK）（亮氨酸焦激肽（LPK）的截短类似物，一种昆虫促肌肽）在脑和内脏器官中的分布。发现该类似物在肾上腺以及脑的下丘脑和海马中有高度蓄积。在其他内脏器官和脑的部分区域也观察到[2-8]-LPK有较少但显著的蓄积。本研究结果证实了我们先前关于标记的天然LPK在大鼠中分布的研究结果。讨论了所得结果对脑功能可能具有的意义。
