[二酰甘油酰基转移酶（DGAT）相关基因的研究进展]

[Progress in the study on diacylgycerol acyltransferase (DGAT)-related genes].

作者信息

Ma Hai-Ming, Shi Qi-Shun, Liu Xiao-Chun

机构信息

College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China.

出版信息

Yi Chuan Xue Bao. 2005 Dec;32(12):1327-32.

PMID:16459663

Abstract

Diacylgycerol Acyltransferase (DGAT) plays an important role in the formation of lipid in different tissues of biological body. DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycerol. This enzyme is coded by both DGAT1 and DGAT2. DGAT1 belongs to the gene family of cholesterol acyltransferase (ACAT). DGAT2 belongs to the gene family of monoacylgycerol acyltransferases (MGAT1). This paper reviewed the structure, location on chromosome and biological effect of DGAT-related genes. The relationship between polymorphism and performance of animal was also discussed.

摘要

二酰甘油酰基转移酶（DGAT）在生物机体不同组织的脂质形成过程中发挥着重要作用。DGAT通过将二酰甘油（DAG）和脂肪酰辅酶A（CoA）转化为三酰甘油，催化三酰甘油（TAG）生物合成的最后一步。该酶由DGAT1和DGAT2编码。DGAT1属于胆固醇酰基转移酶（ACAT）基因家族。DGAT2属于单酰甘油酰基转移酶（MGAT1）基因家族。本文综述了DGAT相关基因的结构、染色体定位及生物学效应。还讨论了多态性与动物性能之间的关系。