[二酰甘油酰基转移酶2（DGAT2）基因的研究进展]

[Research progress on diacylgycerol acyltransferase 2 (DGAT2) gene].

作者信息

Yuan Zheng-Rong, Liu Xiao-Chun, Ma Hai-Ming, Ding Zhao-Yang

机构信息

College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China.

出版信息

Yi Chuan. 2008 Mar;30(3):289-94. doi: 10.3724/sp.j.1005.2008.00289.

DOI:10.3724/sp.j.1005.2008.00289

PMID:18331995

Abstract

Diacylgycerol acyltransferase2 (DGAT2) is an important enzyme in many organisms. DGAT2 catalyzes the final step of triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into TAG. This enzyme is encoded by both DGAT2 and DGAT1 genes. This paper reviews the discovery of the DGAT2 gene, its structure, chromosomal location and biological effect. The relationship between its genetic polymorphisms and animal performance traits is also discussed. The review ends with future prospects.

摘要

二酰甘油酰基转移酶2（DGAT2）是许多生物体中的一种重要酶。DGAT2通过将二酰甘油（DAG）和脂肪酰辅酶A（CoA）转化为三酰甘油（TAG）来催化三酰甘油（TAG）生物合成的最后一步。该酶由DGAT2和DGAT1基因编码。本文综述了DGAT2基因的发现、其结构、染色体定位和生物学效应。还讨论了其基因多态性与动物生产性能性状之间的关系。综述最后展望了未来前景。