Berthier Aurélien, Gobet Françoise, Bugel Hubert, Roquet Laurence, Pfister Christian
Service d'Urologie, CHU de Rouen, France.
Prog Urol. 2005 Sep;15(4):729-32.
Nested variant urothelial carcinoma is a recently identified variant of urothelial carcinoma which is difficult to diagnose due to its resemblance to other benign bladder lesions, such as hyperplasia of Von Brünn nests. The authors present three clinical cases of this variant of urothelial carcinoma and emphasize the importance of clinical, cytological, histological and immunohistochemical criteria for the diagnosis and the need for early and adapted therapeutic management, as this type of bladder tumour, wrongly considered to be benign up until the early 1990s, is just as invasive as high-grade urothelial carcinoma.
嵌套性变异型尿路上皮癌是一种最近才被确认的尿路上皮癌变异型，由于它与其他良性膀胱病变（如冯·布伦巢状增生）相似，因此难以诊断。作者介绍了三例这种变异型尿路上皮癌的临床病例，并强调了临床、细胞学、组织学和免疫组化标准在诊断中的重要性，以及早期和适当治疗管理的必要性，因为这种类型的膀胱肿瘤在20世纪90年代初之前一直被错误地认为是良性的，但其侵袭性与高级别尿路上皮癌一样。
