Frohman E M, Havrdova E, Levinson B, Slanar O
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA.
Mult Scler. 2006 Feb;12(1):108-11. doi: 10.1191/135248506ms1249cr.
We describe two multiple sclerosis patients who developed pancytopenia following treatment with azathioprine. They were found to have the homozygous polymorphism for thiopurine methyltransferase deficiency and recovered after cessation of drug therapy. We review the literature concerning this molecular derangement and underscore the importance of performing surveillance testing for allelic characterization prior to treatment intervention with this agent for immune-mediated disorders.
我们描述了两名在接受硫唑嘌呤治疗后出现全血细胞减少的多发性硬化症患者。他们被发现存在硫嘌呤甲基转移酶缺乏的纯合多态性，在停止药物治疗后康复。我们回顾了有关这种分子紊乱的文献，并强调在使用该药物治疗免疫介导疾病之前进行等位基因特征监测检测的重要性。
