Ashley Thomas
Gen Re LifeHealth, 695 E. Main St, Stamford, Conn 06901, USA.
J Insur Med. 2005;37(4):261-3.
The Prostate Cancer Prevention Trial yields a means to evaluate PSA screening for prostate cancer detection. The receiver operating characteristic curve shows that PSA above 2.5 provides optimum sensitivity and specificity for prostate cancer diagnosis by needle biopsy. However, the maximum positive predictive value of 48% occurs at PSA above 4.0 and does not increase at higher PSA cutpoints. Consideration of test sensitivity and specificity alone is not sufficient for optimal interpretation of test results.
前列腺癌预防试验提供了一种评估前列腺特异性抗原（PSA）筛查用于前列腺癌检测的方法。受试者工作特征曲线显示，PSA高于2.5时，经针吸活检诊断前列腺癌具有最佳的敏感性和特异性。然而，PSA高于4.0时，最大阳性预测值为48%，且在更高的PSA切点时不会增加。仅考虑检测的敏感性和特异性不足以对检测结果进行最佳解读。
