Shimbo Masashi, Tomioka Susumu, Sasaki Makoto, Shima Takayuki, Suzuki Noriyuki, Murakami Shino, Nakatsu Hiroomi, Shimazaki Jun
Department of Urology, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba-shi 260-8670, Japan.
Jpn J Clin Oncol. 2009 Nov;39(11):727-31. doi: 10.1093/jjco/hyp091. Epub 2009 Aug 12.
Detection of prostate cancer needs a biopsy of the prostate. Suspecting cancer from an increase in prostate-specific antigen (PSA) has a high negative rate at an initial prostate biopsy. Cases with negative initial biopsy may be the candidates of subsequent biopsy. For lowering unnecessary repeat biopsy, the use of predictive factors before a repeat biopsy is applied for indication.
Seventy-seven cases with negative initial prostate biopsy received a repeat biopsy and factors for the detection of cancer were examined.
PSA doubling time distinguished a part of cancer cases. Its sensitivity of 30, 50 and 70 months was 36.6%, 30.4% and 10%, respectively. Cancer case did not show PSA doubling time of >100 months in general. Values of PSA transition zone density, %Free/total PSA and PSA velocity were similar between cancer and no cancer cases.
PSA doubling time was one of the predictive factors for the detection of prostate cancer and was valuable for avoiding unnecessary repeat biopsy in some cases.
前列腺癌的检测需要进行前列腺活检。基于前列腺特异性抗原（PSA）升高怀疑患有癌症的患者，初次前列腺活检的阴性率较高。初次活检结果为阴性的病例可能是后续活检的候选对象。为了减少不必要的重复活检，在进行重复活检前可使用预测因素来决定是否进行活检。
对77例初次前列腺活检结果为阴性的患者进行了重复活检，并对癌症检测相关因素进行了检查。
PSA倍增时间可区分出一部分癌症病例。其在30、50和70个月时的敏感度分别为36.6%、30.4%和10%。一般来说，癌症病例的PSA倍增时间不会超过100个月。癌症患者与非癌症患者的PSA移行带密度、游离PSA/总PSA比值及PSA速率值相似。
PSA倍增时间是前列腺癌检测的预测因素之一，在某些情况下对于避免不必要的重复活检具有重要价值。
