Bonini Massimo, Rossi Simona, Karlsson Göran, Almgren Mats, Lo Nostro Pierandrea, Baglioni Piero
Department of Chemistry and CSGI, University of Florence, 50019 Sesto Fiorentino (Firenze), Italy.
Langmuir. 2006 Feb 14;22(4):1478-84. doi: 10.1021/la052878f.
In this article, we report evidence of beta-cyclodextrin (beta-CD) self-aggregation in water. A critical aggregation concentration (cac) between 2 and 3 mM was determined by using dynamic (DLS) and static (SLS) light scattering to investigate the presence of beta-cyclodextrin aggregates. Transmission electron microscopy at cryogenic temperature (Cryo-TEM) was used to detect the structural features of cyclodextrin self-aggregates. The results show the occurrence of polymorphism depending on the beta-CD concentration: polydisperse nearly spherical objects with diameters of about 100 nm are present at lower concentrations, whereas micrometer planar aggregates are predominant at higher concentrations.
在本文中，我们报告了β-环糊精（β-CD）在水中自聚集的证据。通过动态光散射（DLS）和静态光散射（SLS）来研究β-环糊精聚集体的存在，从而确定了2至3 mM之间的临界聚集浓度（cac）。利用低温透射电子显微镜（Cryo-TEM）检测环糊精自聚集体的结构特征。结果表明，根据β-CD浓度会出现多晶型现象：在较低浓度下存在直径约为100 nm的多分散近球形物体，而在较高浓度下微米级平面聚集体占主导地位。
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