Christaki Stamatia, Spanidi Eleni, Panagiotidou Eleni, Athanasopoulou Sophia, Kyriakoudi Anastasia, Mourtzinos Ioannis, Gardikis Konstantinos
Laboratory of Food Chemistry and Biochemistry, School of Agriculture, Aristotle University of Thessaloniki (AUTH), 54124 Thessaloniki, Greece.
APIVITA SA, Industrial Park, Markopoulo, 19003 Athens, Greece.
Pharmaceuticals (Basel). 2023 Sep 8;16(9):1274. doi: 10.3390/ph16091274.
Cyclodextrins have gained significant and established attention as versatile carriers for the delivery of bioactive compounds derived from natural sources in various applications, including medicine, food and cosmetics. Their toroidal structure and hydrophobic cavity render them ideal candidates for encapsulating and solubilizing hydrophobic and poorly soluble compounds. Most medicinal, food and cosmetic ingredients share the challenges of hydrophobicity and degradation that can be effectively addressed by various cyclodextrin types. Though not new or novel-their first applications appeared in the market in the 1970s-their versatility has inspired numerous developments, either on the academic or industrial level. This review article provides an overview of the ever-growing applications of cyclodextrins in the delivery of bioactive compounds from natural sources and their potential application benefits.
环糊精作为一种多功能载体，在医学、食品和化妆品等各种应用中用于递送天然来源的生物活性化合物，已经获得了广泛且确定的关注。它们的环形结构和疏水腔使其成为包封和增溶疏水及难溶性化合物的理想候选物。大多数药用、食品和化妆品成分都面临着疏水性和降解的挑战，而各种类型的环糊精可以有效解决这些问题。尽管环糊精并非新事物——它们在20世纪70年代首次进入市场应用——但其多功能性在学术和工业层面都引发了众多发展。这篇综述文章概述了环糊精在递送天然来源生物活性化合物方面不断增长的应用及其潜在的应用益处。
