Müller A, Krombholz B, Pott G, Machnik G, Vollandt R, Reinhardt M, Jorke D
Department of Internal Medicine, University of Jena, FRG.
Clin Chim Acta. 1991 Feb 28;197(1):59-66. doi: 10.1016/0009-8981(91)90348-g.
The concentration of the N-terminal peptide of procollagen III and the activity of collagen peptidase (PZ-peptidase) were measured in sera from 92 patients with chronic liver disease. In patients with liver cirrhosis and chronic hepatitis with transformation of liver structure, high values were found for both variables compared with hepatoses and chronic hepatitis without transformation. The concentration of procollagen III peptide and the activity of collagen peptidase in serum increased with increasing degrees of fibrosis and, even more markedly, with increasing degrees of mesenchymal activity in the liver.
对92例慢性肝病患者血清中的前胶原III N端肽浓度和胶原肽酶（PZ-肽酶）活性进行了测定。在肝硬化患者以及肝结构发生改变的慢性肝炎患者中，与肝实质病变和未发生结构改变的慢性肝炎患者相比，这两个变量的值均较高。血清中前胶原III肽的浓度和胶原肽酶的活性随着肝纤维化程度的增加而升高，并且在肝脏间充质活动程度增加时升高更为明显。
