Trinchet J C, Hartmann D J, Pateron D, Laarif M, Callard P, Ville G, Beaugrand M
Service d'Hépato-Gastroentérologie, Hôpital Jean Verdier, Bondy, France.
J Hepatol. 1991 Mar;12(2):139-44. doi: 10.1016/0168-8278(91)90929-6.
The aim of this study was to compare serum N-terminal peptide of type III procollagen to aminotransferases and gamma-globulins as a marker for histological activity in patients with chronic hepatitis and to assess the role of type I collagen, a new serum marker, as a marker of fibrosis in these patients. Sixty patients with biopsy-proven chronic hepatitis were included in this study. Liver disease was virus B-related in 29, autoimmune in five, drug-induced in five, and of unknown etiology in 21. Each biopsy was independently assessed by two liver pathologists. Two histological scores, a score of activity and a score of fibrosis, were established. Serum N-terminal peptide of type III procollagen and type I collagen were assayed by liquid phase RIA. Significant correlations were noted between serum N-terminal peptide of type III procollagen and scores of activity (r = 0.70, p less than 10(-4)) and fibrosis (r = 0.45, p = 0.0005), and between serum type I collagen and scores of activity (r = 0.46, p = 0.0004) and fibrosis (r = 0.67, p less than 10(-4)). When the correlation between scores of activity and fibrosis (r = 0.52, p = 10(-4)) was considered by partial correlation, serum N-terminal peptide of type III procollagen was correlated with the score of activity (r = 0.63, p less than 10(-3)) but not with the score of fibrosis, and serum type I collagen was correlated with the score of fibrosis (r = 0.58, p less than 10(-3)), but not with the score of activity.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究旨在比较血清III型前胶原N端肽与转氨酶及γ-球蛋白，作为慢性肝炎患者组织学活性的标志物，并评估新型血清标志物I型胶原作为这些患者纤维化标志物的作用。本研究纳入了60例经活检证实为慢性肝炎的患者。其中29例肝病与乙型病毒相关，5例为自身免疫性，5例为药物性，21例病因不明。每例活检均由两位肝脏病理学家独立评估。建立了两个组织学评分，即活性评分和纤维化评分。采用液相放射免疫分析法检测血清III型前胶原N端肽和I型胶原。结果发现，血清III型前胶原N端肽与活性评分（r = 0.70，p < 10⁻⁴）及纤维化评分（r = 0.45，p = 0.0005）之间存在显著相关性，血清I型胶原与活性评分（r = 0.46，p = 0.0004）及纤维化评分（r = 0.67，p < 10⁻⁴）之间也存在显著相关性。当通过偏相关分析考虑活性评分与纤维化评分之间的相关性（r = 0.52，p = 10⁻⁴）时，血清III型前胶原N端肽与活性评分相关（r = 0.63，p < 10⁻³），但与纤维化评分无关；血清I型胶原与纤维化评分相关（r = 0.58，p < 10⁻³），但与活性评分无关。（摘要截断于250字）
