Cunningham Mauro César Quintão Silva, Maia Débora Palma, Teixeira Antonio Lúcio, Cardoso Francisco
Setor de Neurologia, Hospital das Clínicas, UFMG, Belo Horizonte MG, Brazil.
Parkinsonism Relat Disord. 2006 Apr;12(3):165-7. doi: 10.1016/j.parkreldis.2005.11.003. Epub 2006 Feb 3.
Sydenham's chorea (SC) is a disorder associated with rheumatic fever and related to Streptococcus-induced immune reaction cross-reactive with basal ganglia antigens. Obsessive-compulsive disorder and other behavioral abnormalities have been described in SC. There are scarce data of cognitive function in this condition.
To assess verbal fluency in patients with SC.
We have compared the semantic (SVF) and phonemic verbal fluency (PVF) of 20 subjects with SC and 40 controls matched by age, gender and years of school.
The scores of the control group on the SVF and PVF tests were 26.3 +/- 5.7 and 18.0 +/- 6.4 whereas the SC patients scored 25.1 +/- 6.9 and 12.5 +/- 8.2. PVF was significantly decreased in the SC group (p < 0.01).
SC is associated with reduction of PVF. This finding may reflect disruption of the dorsolateral prefrontal-striatal circuit caused by the auto-immune process characteristic of SC.
Sydenham舞蹈病（SC）是一种与风湿热相关的疾病，与链球菌诱导的、与基底节抗原发生交叉反应的免疫反应有关。SC患者中曾有强迫症及其他行为异常的描述。关于这种疾病的认知功能的数据很少。
评估SC患者的语言流畅性。
我们比较了20例SC患者和40例年龄、性别及受教育年限相匹配的对照者的语义语言流畅性（SVF）和音素语言流畅性（PVF）。
对照组在SVF和PVF测试中的得分分别为26.3±5.7和18.0±6.4，而SC患者的得分分别为25.1±6.9和12.5±8.2。SC组的PVF显著降低（p<0.01）。
SC与PVF降低有关。这一发现可能反映了SC自身免疫过程导致的背外侧前额叶-纹状体回路的破坏。
