Swedo S E, Rapoport J L, Cheslow D L, Leonard H L, Ayoub E M, Hosier D M, Wald E R
Child Psychiatry Branch, NIMH, Bethesda, MD 20892.
Am J Psychiatry. 1989 Feb;146(2):246-9. doi: 10.1176/ajp.146.2.246.
The 20-item Leyton Obsessional Inventory--Child Version was completed by children and adolescents who had had Sydenham's chorea (N = 23) or rheumatic fever without chorea (N = 14). The Sydenham's chorea subjects had significantly more obsessive thoughts and compulsive behaviors and significantly greater interference from these behaviors. Three Sydenham's chorea patients but no rheumatic fever patients had substantial obsessional interference and met criteria for obsessive-compulsive disorder when interviewed by telephone. This suggests that obsessive-compulsive disorder, at least in some patients, may be due to basal ganglia dysfunction.
20项莱顿强迫观念量表儿童版由患有Sydenham舞蹈病（N = 23）或无舞蹈病的风湿热（N = 14）的儿童和青少年完成。患有Sydenham舞蹈病的受试者有明显更多的强迫观念和强迫行为，且这些行为造成的干扰明显更大。3名患有Sydenham舞蹈病的患者，但没有风湿热患者，存在严重的强迫观念干扰，在电话访谈时符合强迫症标准。这表明，强迫症至少在某些患者中可能是由于基底神经节功能障碍所致。
