Sekar Yokananth, Moon Tae Chul, Muñoz Samira, Befus A Dean
Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Immunol Res. 2005;33(3):223-39. doi: 10.1385/IR:33:3:223.
Mast cells (MC) are important effector cells in allergic disorders. Recently, the role of MC in innate and adaptive immunity is gaining prominence. Nitric oxide is an important signaling molecule and its production in mast cell has been reported widely. However, controversy exists about whether MC produce NO. This review addresses the role of NO in MC biology and the reasons behind the controversy and discusses effects of NO in regulation of MC phenotype and function.
肥大细胞（MC）是过敏性疾病中的重要效应细胞。近来，MC在固有免疫和适应性免疫中的作用日益显著。一氧化氮是一种重要的信号分子，其在肥大细胞中的产生已被广泛报道。然而，关于MC是否产生一氧化氮存在争议。本综述阐述了一氧化氮在MC生物学中的作用以及争议背后的原因，并讨论了一氧化氮在调节MC表型和功能方面的作用。
