来自刺茄地下部分的甾体苷类化合物。
Steroidal glycosides from the underground parts of Solanum sodomaeum.
作者信息
Ono Masateru, Nishimura Kazuya, Suzuki Keita, Fukushima Takeshi, Igoshi Keiji, Yoshimitsu Hitoshi, Ikeda Tsuyoshi, Nohara Toshihiro
机构信息
School of Agriculture, Kyushu Tokai University, Kumamoto, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2006 Feb;54(2):230-3. doi: 10.1248/cpb.54.230.
A new steroidal glycoside has been isolated from the underground parts of Solanum sodomaeum L., along with seven known steroidal glycosides. Their chemical structures were determined on the basis of spectroscopic data and chemical evidence, and the structure of one known pregnane type glycoside was corrected. In addition, their antiproliferative activity against human promyelocytic leukemia (HL-60) cells was investigated, and five compounds exhibited stronger activity than cisplatin.
从刺天茄的地下部分分离出一种新的甾体糖苷，以及七种已知的甾体糖苷。根据光谱数据和化学证据确定了它们的化学结构，并对一种已知的孕烷型糖苷的结构进行了修正。此外，还研究了它们对人早幼粒细胞白血病（HL-60）细胞的抗增殖活性，有五种化合物表现出比顺铂更强的活性。
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