Mimaki Y, Yokosuka A, Sashida Y
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
J Nat Prod. 2000 Nov;63(11):1519-23. doi: 10.1021/np000230r.
A chemical investigation of the aerial parts of Polianthes tuberosa resulted in the isolation of a new bisdesmosidic cholestane glycoside (1) and three new spirostanol saponins (2-4), along with a known cholestane glycoside. The structures of new glycosides were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity on HL-60 human promyelocytic leukemia cells.
对晚香玉地上部分进行化学研究，结果分离出一种新的双糖苷甾体胆烷糖苷（1）和三种新的螺旋甾烷醇皂苷（2 - 4），以及一种已知的甾体胆烷糖苷。通过光谱分析，包括二维核磁共振光谱数据和水解裂解结果，确定了新糖苷的结构。对分离得到的化合物进行了对HL - 60人早幼粒细胞白血病细胞的细胞毒性活性评估。
