舌根部鳞状细胞癌的根治性放疗

Definitive radiotherapy for squamous cell carcinoma of the base of tongue.

作者信息

Mendenhall William M, Morris Christopher G, Amdur Robert J, Hinerman Russell W, Werning John W, Villaret Douglas B

机构信息

Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32610-0385, USA.

出版信息

Am J Clin Oncol. 2006 Feb;29(1):32-9. doi: 10.1097/01.coc.0000189680.60262.eb.

DOI:10.1097/01.coc.0000189680.60262.eb

PMID:16462500

Abstract

OBJECTIVE

To evaluate definitive radiotherapy (RT) for treatment of base of tongue cancer.

METHODS

There were 333 patients with squamous cell carcinoma of the base of tongue treated with definitive RT and had follow-up from 0.2 to 26.2 years. Follow-up on living patients ranged from 1.2 to 26.2 years (median, 6.6 years).

RESULTS

Local control rates at 5 years were: T1, 98%; T2, 92%; T3, 82%; and T4, 53%. The 5-year rates of local-regional control rates were: I-II, 100%; III, 82%; IVA, 87%; and IVB, 58%. The rates of absolute and cause-specific survival at 5 years were as follows: I-II, 67% and 91%; III, 66% and 77%; IVA, 67% and 84%; and IVB, 33% and 45%. Severe complications developed in 52 patients (16%).

CONCLUSION

Our data and review of the pertinent literature reveal that the local-regional control rates and survival rates after RT were comparable to those after surgery, and the morbidity associated with RT was less.

摘要

目的

评估根治性放疗（RT）治疗舌根癌的效果。

方法

333例舌根鳞状细胞癌患者接受了根治性放疗，并进行了0.2至26.2年的随访。存活患者的随访时间为1.2至26.2年（中位数为6.6年）。

结果

5年局部控制率分别为：T1期98%；T2期92%；T3期82%；T4期53%。5年局部区域控制率分别为：I-II期100%；III期82%；IVA期87%；IVB期58%。5年绝对生存率和病因特异性生存率如下：I-II期分别为67%和91%；III期分别为66%和77%；IVA期分别为67%和84%；IVB期分别为33%和45%。52例患者（16%）出现严重并发症。