Watkins Hugh, Farrall Martin
Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 9DU, UK.
Nat Rev Genet. 2006 Mar;7(3):163-73. doi: 10.1038/nrg1805.
Family history is an important independent risk factor for coronary artery disease (CAD), and identification of susceptibility genes for this common, complex disease is a vital goal. Although there has been considerable success in identifying genetic variants that influence well-known risk factors, such as cholesterol levels, progress in unearthing novel CAD genes has been slow. However, advances are now being made through the application of large-scale, systematic, genome-wide approaches. Recent findings particularly highlight the link between CAD and inflammation and immunity, and highlight the biological insights to be gained from a genetic understanding of the world's biggest killer.
家族病史是冠状动脉疾病（CAD）的一个重要独立风险因素，识别这种常见复杂疾病的易感基因是一个至关重要的目标。尽管在识别影响诸如胆固醇水平等知名风险因素的基因变异方面已经取得了相当大的成功，但在挖掘新的CAD基因方面进展缓慢。然而，现在通过应用大规模、系统性的全基因组方法正在取得进展。最近的研究结果特别强调了CAD与炎症和免疫之间的联系，并突出了从对全球最大杀手的基因理解中获得的生物学见解。
