Geppert Anita M
Katedra i Klinika Neurologii, Akademia Medyczna, ul. Przybyszewskiego 49, 60-355 Poznań.
Neurol Neurochir Pol. 2006 Jan-Feb;40(1):57-61.
Alzheimer's disease is a complex neurodegenerative disorder. Several risk factors have been reported and compiled from genetic and epidemiological studies. Many theories on the cause of Alzheimer's disease have been proposed over the past. Amyloid hypothesis is still the most important one and guides a lot of scientific research on AD. But there is general consent that amyloid deposits are the products of degenerating neurons, not a cause of degeneration. Recently, epidemiological data for the correlation between HSV-1 infection and AD have been collected. It was revealed that HSV-1 is present in a latent form in the brains of a high proportion of elderly people and is a risk factor for AD in carriers of APOEepsilon4. On the other hand, there is negative evidence for HSV-1 as a risk factor of APOEepsilon4 positive AD cases. Finally, some investigations raise a possibility that viruses other than HSV-1 may influence Alzheimer's disease. In the present paper the possible role of HSV-1 infection in pathology of AD is discussed.
阿尔茨海默病是一种复杂的神经退行性疾病。已从遗传学和流行病学研究中报告并汇总了多种风险因素。过去人们提出了许多关于阿尔茨海默病病因的理论。淀粉样蛋白假说仍然是最重要的一个，并指导了许多关于阿尔茨海默病的科学研究。但人们普遍认为淀粉样蛋白沉积是神经元退化的产物，而非退化的原因。最近，已收集到关于单纯疱疹病毒1型（HSV-1）感染与阿尔茨海默病之间相关性的流行病学数据。结果显示，HSV-1以潜伏形式存在于高比例老年人的大脑中，并且是APOEε4携带者患阿尔茨海默病的一个风险因素。另一方面，有负面证据表明HSV-1并非APOEε4阳性阿尔茨海默病病例的风险因素。最后，一些调查提出了一种可能性，即除HSV-1之外的其他病毒可能会影响阿尔茨海默病。在本文中，将讨论HSV-1感染在阿尔茨海默病病理学中的可能作用。
