Piédrola Angulo Gonzalo
An R Acad Nac Med (Madr). 2005;122(2):377-89; discussion 389-92.
In this work the possible etiologic relationship among the multiple sclerosis and the herpesvirus 6 (VHH-6) has been studied, subject debated in the last years. They have been carried out two studies using blood and LCR of sick of multiple sclerosis, and control in healthy fellows and with other neurological illnesses. The followed techniques are described to isolate the virus, their DNA, and the antibodies IgG and IgA in front of the VHH-6. The presente of the VHH-6 has not been demonstrated neither of its DNA in any case, but if it has been proved, with statistical significance that in the sick persons with buds of multiple sclerosis, the antibodies of the type IgG, as much in plasm as in LCR, was more present and in higher levels that in the controls.
在这项研究中,对多发性硬化症与疱疹病毒6型(VHH - 6)之间可能的病因关系进行了研究,这是近年来备受争议的话题。对多发性硬化症患者的血液和淋巴细胞进行了两项研究,并与健康人和其他神经系统疾病患者作为对照。描述了用于分离病毒、其DNA以及针对VHH - 6的IgG和IgA抗体的后续技术。在任何情况下,均未证实VHH - 6及其DNA的存在,但已证明,具有统计学意义的是,在患有多发性硬化症发作的患者中,IgG型抗体在血浆和淋巴细胞中均比对照组更常见且水平更高。