Mayne M, Krishnan J, Metz L, Nath A, Auty A, Sahai B M, Power C
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
Ann Neurol. 1998 Sep;44(3):391-4. doi: 10.1002/ana.410440317.
Several studies have suggested an association between human herpesvirus 6 (HHV-6) infection and multiple sclerosis. As HHV-6 is predominantly a T-cell tropic virus, we examined the frequency of detection of HHV-6 genome in peripheral blood mononuclear cells from relapsing-remitting (n = 32) and chronic progressive (n = 14) patients and from healthy (n = 17) and neurological (n = 7) controls. Two sensitive polymerase chain reaction assays were used to target different regions within the HHV-6 genome. Depending on the polymerase chain reaction assay used, the detection of HHV-6 genome ranged from 11.7 to 23.5% (controls), 3.1 to 23.0% (relapsing-remitting), and 14.2 to 28.5% (chronic progressive). Although these observations do not exclude a pathogenic role for HHV-6 in multiple sclerosis, they indicate a lack of correlation between HHV-6 infection of peripheral blood mononuclear cells and the development of multiple sclerosis.
多项研究表明，人类疱疹病毒6型（HHV-6）感染与多发性硬化症之间存在关联。由于HHV-6主要是一种嗜T细胞病毒，我们检测了复发缓解型（n = 32）和慢性进展型（n = 14）患者以及健康对照（n = 17）和神经疾病对照（n = 7）外周血单个核细胞中HHV-6基因组的检测频率。使用两种灵敏的聚合酶链反应检测法针对HHV-6基因组内的不同区域。根据所使用的聚合酶链反应检测法，HHV-6基因组的检测率在对照组中为11.7%至23.5%，在复发缓解型患者中为3.1%至23.0%，在慢性进展型患者中为14.2%至28.5%。尽管这些观察结果不排除HHV-6在多发性硬化症中的致病作用，但它们表明外周血单个核细胞的HHV-6感染与多发性硬化症的发生之间缺乏相关性。
