Csernus V, Haláz B
Neuroendocrinology. 1975;17(1):18-26. doi: 10.1159/000122337.
Resting and stress-induced plasma corticosterone concentrations in adult male hypophysectomized rats bearing a pituitary homograft in the hypothalamus were determined fluorimetrically. Plasma corticosterone resting levels were maintained and a significant elevation of these levels in response to stress occurred only in those rats in which the graft was in the medial basal hypothalamus (hypophysiotrophic area, HTA) and the implant was connected with the median eminence. If these latter connections of the graft in the HTA did not exist, resting plasma corticosterone concentrations were reduced and the applied stress did not induce any elevation of the low pre-stress levels. On the basis of the present and previous findings, it is assumed that the site of CRF production is the median eminence region.
用荧光法测定了成年雄性垂体切除大鼠在下丘脑植入垂体同种移植物后的静息和应激诱导血浆皮质酮浓度。血浆皮质酮静息水平得以维持，且仅在移植物位于下丘脑内侧基底部（促垂体区，HTA）且植入物与正中隆起相连的大鼠中，应激时这些水平才会显著升高。如果HTA中移植物不存在后一种连接，静息血浆皮质酮浓度会降低，施加的应激也不会引起低应激前水平的任何升高。基于目前及先前的研究结果，推测促肾上腺皮质激素释放因子（CRF）的产生部位是正中隆起区域。
