Wiczkowski Andrzej, Gawron Katarzyna, Birkner Ewa, Zalejska-Fiolka Jolanta, Dziambor Andrzej Piotr, Ciarkowska Jolanta, Spausta Grazyna
Katedra i Zakład Ogólnej Biologii Lekarskiej Slaskiej Akademii Medycznej w Zabrzu.
Przegl Lek. 2005;62(7):667-70.
The aim of this study was oxidative stress evaluation as reflected by antioxidant status and lipid peroxidation products levels in plasma and erythrocytes from CHC patients (chronic hepatitis C patients). Antioxidant status, markers of lipid peroxidation and liver function were measured in erythrocytes and plasma from 29 CHC patients and from 26 matched healthy controls. Plasma and erythrocytes MDA (malondialdehyde) levels were statistically decreased in CHC patients as compared with healthy controls while erythrocytes CuZnSOD (superoxide dismutase--cytoplasmic enzyme contains copper and zinc) activity was statistically increased in CHC patients as compared to healthy subjects. Plasma MDA levels correlated positively with AST (aspartate aminotransferase), ALT (alanine aminotransferase), aldolase and LDH (lactate dehydrogenase) activity. GPX (glutathione peroxidase) activity correlated negatively with erythrocytes and plasma MDA levels and CuZnSOD activity correlated negatively with LDH, aldolase, AST activity and with plasma MDA levels.
Results of antioxidant status in CHC patients indicate oxidative stress development and efficient function of intracellular antioxidants.
本研究旨在通过慢性丙型肝炎（CHC）患者血浆和红细胞中的抗氧化状态及脂质过氧化产物水平来评估氧化应激。对29例CHC患者及26例匹配的健康对照者的红细胞和血浆进行了抗氧化状态、脂质过氧化标志物及肝功能检测。与健康对照相比，CHC患者血浆和红细胞中的丙二醛（MDA）水平在统计学上降低，而与健康受试者相比，CHC患者红细胞中的铜锌超氧化物歧化酶（CuZnSOD，一种含铜和锌的细胞质超氧化物歧化酶）活性在统计学上升高。血浆MDA水平与天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、醛缩酶和乳酸脱氢酶（LDH）活性呈正相关。谷胱甘肽过氧化物酶（GPX）活性与红细胞和血浆MDA水平呈负相关，CuZnSOD活性与LDH、醛缩酶、AST活性及血浆MDA水平呈负相关。
CHC患者抗氧化状态的结果表明氧化应激的发生及细胞内抗氧化剂的有效功能。
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