Montazerifar Farzaneh, Hashemi Mohammad, Karajibani Mansour, Sanadgol Houshang, Dikshit Madhurima
Department of Nutrition, Zahedan University of Medical Sciences, Zahedan, Iran.
Saudi J Kidney Dis Transpl. 2012 Mar;23(2):274-9.
Oxidative stress often occurs in chronic hemodialysis (HD). The aim of the present study was to determine plasma malondialdehyde (MDA) level for lipid peroxidation product and erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as enzymatic antioxidants. Thirty-one HD patients (aged 50.3 ± 14.9 years) who were dialyzed three times per week and 31 healthy subjects (aged 47.8 ± 13.9 years) were enrolled. The results showed lower enzymatic antioxidants activity (GPx, SOD) and higher MDA levels in comparison with control subjects. In addition, SOD and GPx activities significantly decreased and MDA increased after HD. We also found that there was a significantly negative correlation between SOD and GPx with MDA. The results suggest that elevated level of plasma MDA and reduced activities of SOD and GPx can be caused oxidative stress, which may play a critical role in HD complications.
氧化应激常发生于慢性血液透析（HD）过程中。本研究旨在测定脂质过氧化产物血浆丙二醛（MDA）水平以及作为酶性抗氧化剂的红细胞超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）活性。纳入了31例每周透析3次的HD患者（年龄50.3±14.9岁）和31例健康受试者（年龄47.8±13.9岁）。结果显示，与对照组相比，酶性抗氧化剂活性（GPx、SOD）较低，MDA水平较高。此外，血液透析后SOD和GPx活性显著降低，MDA升高。我们还发现SOD和GPx与MDA之间存在显著负相关。结果表明，血浆MDA水平升高以及SOD和GPx活性降低可能导致氧化应激，这可能在HD并发症中起关键作用。
