[囊性纤维化跨膜传导调节因子在鼻息肉和正常鼻甲黏膜上皮细胞中的表达]

[Expressions of cystic fibrosis transmembrane conductance regulator in epithelial cells of nasal polyps and normal turbinate mucosae].

作者信息

Lin Shuchun, Lin Guojing, Huang Jianmin, Jiang Zhangzhou

机构信息

Department of Otorhinolaryngology, Union Hospital, Affiliated to Fujian Medical University, Fuzhou, 350001, China.

出版信息

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Nov;19(22):1037-9.

PMID:16463769

Abstract

OBJECTIVE

To investigate the role of cystic fibrosis transmembrane conductance regulator (CFTR) in human nasal polyps.

METHOD

CFTR were studied in 28 cases of nasal polyps and 7 cases of normal turbinate mucosae with immunochemistry staining.

RESULT

(1) CFTR was detected in the two tissues and localized mainly in epithelial cells and secretory cells. Its staining showed a more prominent feature in nasal polyps than in normal turbinate mucosae. CFTR showed a typical apical distribution in the normal turbinate mucosae whereas, in the nasal polyps, CFTR demonstrated the other pattern of localization comprising cytoplasmic distribution and typical apical location. (2) Both the CFTR staining intensity of apical and cytoplasmic distribution in the epithelial cell layer from nasal polyps were higher than those from turbinates (P < 0.05, P < 0.05 respectively).

CONCLUSION

Over expression and dysfunction of the chloride channels CFTR may play a role in the formation of nasal polyps.

摘要

目的

探讨囊性纤维化跨膜传导调节因子（CFTR）在人鼻息肉中的作用。

方法

采用免疫组化染色法对28例鼻息肉组织和7例正常鼻甲黏膜组织中的CFTR进行研究。

结果

（1）两种组织中均检测到CFTR，主要定位于上皮细胞和分泌细胞。其染色在鼻息肉中比在正常鼻甲黏膜中表现更为突出。CFTR在正常鼻甲黏膜中呈典型的顶端分布，而在鼻息肉中，CFTR表现出包括胞质分布和典型顶端定位的另一种定位模式。（2）鼻息肉上皮细胞层中CFTR顶端和胞质分布的染色强度均高于鼻甲（分别为P < 0.05，P < 0.05）。