水通道蛋白5在人鼻息肉中的表达及分布
[Expression and distribution of aquaporin-5 in human nasal polyps].
作者信息
Li Zhihai, Gao Qixue
机构信息
Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Feb;19(4):162-4.
OBJECTIVE
To investigate the distribution and expression of aquaporin-5 (AQP-5) in nasal polyps and explore the role of AQP-5 in the formation of nasal polyps and the normal function of AQP-5 in the inferior turbinate.
METHOD
AQP-5 were studied in 30 samples nasal polyps and 12 samples of inferior turbinates with immunochemistric staing.
RESULT
The level of AQP-5 positive cells in the serous cells from nasal polyps were lesser than that from inferior turbinate, and the level of AQP-5 positive cells in the blood vessel endothelium from nasal polyps were more than that from inferior turbinate.
CONCLUSION
AQP-5 may play the role in both the formation of nasal polyps and the function of normal nasal mucous membrane.
目的
研究水通道蛋白5（AQP-5）在鼻息肉中的分布及表达情况，探讨AQP-5在鼻息肉形成中的作用以及其在鼻下甲中的正常功能。
方法
采用免疫组织化学染色法对30例鼻息肉组织标本和12例鼻下甲组织标本进行AQP-5研究。
结果
鼻息肉浆液细胞中AQP-5阳性细胞水平低于鼻下甲，鼻息肉血管内皮中AQP-5阳性细胞水平高于鼻下甲。
结论
AQP-5可能在鼻息肉形成及正常鼻黏膜功能中均发挥作用。
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