Smirnova Marina G, Kiselev Sergei L, Gnuchev Nickolai V, Birchall John P, Pearson Jeffrey P
Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
Eur Cytokine Netw. 2002 Apr-Jun;13(2):161-72.
Inflammation in the middle ear mucosa, caused usually by bacterial and viral pathogens, is the primary event in the middle ear predisposing the development of otitis media with effusion (OME). Numerous inflammatory mediators have been identified in OME. However, cytokines play a central role as initiators, mediators and regulators of middle ear inflammation and subsequent molecular-pathological processes in middle ear tissues, leading to histopathological changes in the middle ear cavity and the pathogenesis of OME. In this article, we aim to present an overview of current research developments in the pro-inflammatory cytokine involvement in the aetiology of otitis media with effusion.
中耳黏膜炎症通常由细菌和病毒病原体引起，是中耳积液性中耳炎（OME）发生发展的主要诱因。在OME中已鉴定出多种炎症介质。然而，细胞因子作为中耳炎症及中耳组织后续分子病理过程的启动剂、介质和调节剂发挥着核心作用，导致中耳腔组织病理学变化及OME的发病机制。在本文中，我们旨在概述促炎细胞因子参与积液性中耳炎病因学的当前研究进展。
