Goolamali S I, Pakianathan M
Department of Genito-Urinary and HIV Medicine, The Courtyard Clinic, St George's Hospital, Blackshaw Road, Tooting, London SW17 OQT, UK.
Int J STD AIDS. 2006 Feb;17(2):135-6. doi: 10.1258/095646206775455658.
Squamous cell carcinoma of the penis is an uncommon cancer, though in one study it accounted for 90% of all penile cancers. Its association with balanitis xerotica obliterans (BXO) is a rare though recognized occurrence. We describe a case of a 46-year-old Caucasian male who first presented to our open-access clinic with a mild phimosis. An elective circumcision was performed and histological examination of the circumcision specimen showed BXO. He was lost to follow-up but re-presented three years later with a persistent tender penile ulcer which on biopsy showed no obvious sinister pathology. He returned a further two years later with a short history of bleeding from the ulcer, and another biopsy now confirmed penile squamous cell carcinoma. Our case emphasizes the importance of regular review of patients with BXO, in particular those with persistent symptoms.
阴茎鳞状细胞癌是一种罕见的癌症，不过在一项研究中，它占所有阴茎癌的90%。它与闭塞性干燥性龟头炎（BXO）的关联虽罕见但已得到确认。我们描述了一例46岁的白种男性病例，他最初因轻度包茎到我们的开放式诊所就诊。进行了择期包皮环切术，包皮环切标本的组织学检查显示为BXO。他失访了，但三年后再次就诊，出现持续的阴茎压痛性溃疡，活检未显示明显的恶性病变。又过了两年，他因溃疡短期出血再次前来，此时另一活检确诊为阴茎鳞状细胞癌。我们的病例强调了对BXO患者，尤其是有持续症状的患者进行定期复查的重要性。
