Mori Tomohisa, Ito Shinobu, Kita Taizo, Narita Minoru, Suzuki Tsutomu, Sawaguchi Toshiko
Department of Legal Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Eur J Pharmacol. 2006 Feb 17;532(1-2):81-7. doi: 10.1016/j.ejphar.2005.12.035. Epub 2006 Feb 7.
Opioid receptor agonists can differentially modify the behavioral effects of direct/indirect dopamine receptor agonists, such as methamphetamine, cocaine and apomorphine. However, the effects of opioid receptor agonists on high-dose methamphetamine-induced behavior have not yet been clarified. Therefore, the present study was undertaken to investigate the effects of mu (morphine)-, delta (SNC80)- and kappa (U50,488H)-opioid receptor agonists on methamphetamine-induced self-injurious behavior and locomotor activity in mice. Methamphetamine (20 mg/kg) induced severe self-injurious behavior. In a combination test, some opioid receptor agonists significantly attenuated methamphetamine-induced self-injurious behavior, with potencies in the order morphine>buprenorphine (mu-opioid and kappa-opioid receptor agonist/antagonist) >U50,488H, as maximum effects. These results suggest that the stimulation of mu- and kappa-opioid receptors plays an inhibitory role in high-dose methamphetamine-induced stereotypic self-injurious behavior in mice, without affecting locomotor activity.
阿片受体激动剂可以不同程度地改变直接/间接多巴胺受体激动剂（如甲基苯丙胺、可卡因和阿扑吗啡）的行为效应。然而，阿片受体激动剂对高剂量甲基苯丙胺诱导行为的影响尚未阐明。因此，本研究旨在探讨μ（吗啡）-、δ（SNC80）-和κ（U50,488H）-阿片受体激动剂对甲基苯丙胺诱导的小鼠自伤行为和运动活动的影响。甲基苯丙胺（20mg/kg）诱导严重的自伤行为。在联合试验中，一些阿片受体激动剂显著减轻了甲基苯丙胺诱导的自伤行为，其效力顺序为吗啡>丁丙诺啡（μ-阿片和κ-阿片受体激动剂/拮抗剂）>U50,488H，为最大效应。这些结果表明，刺激μ-和κ-阿片受体对高剂量甲基苯丙胺诱导的小鼠刻板自伤行为起抑制作用，而不影响运动活动。
