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在兽医诊所及家庭环境中,耐甲氧西林金黄色葡萄球菌在宠物与人类之间的疑似传播。

Suspected transmission of methicillin-resistant Staphylococcus aureus between domestic pets and humans in veterinary clinics and in the household.

作者信息

Weese J S, Dick H, Willey B M, McGeer A, Kreiswirth B N, Innis B, Low D E

机构信息

Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ont. (Weese), Canada N1G 2W1.

出版信息

Vet Microbiol. 2006 Jun 15;115(1-3):148-55. doi: 10.1016/j.vetmic.2006.01.004. Epub 2006 Feb 7.

Abstract

OBJECTIVE

To describe MRSA infection and colonization in household pets, and transmission of MRSA between animals and humans.

METHODS

MRSA infection and colonization in household pets and human contacts were evaluated during investigations initiated after identification of MRSA infection or colonization of a household pet in order to determine if there had been transmission between animals and humans. All MRSA isolates were screened for Panton-Valentine leukocidin (PVL) genes by use of polymerase chain reaction, and isolate relatedness was determined by use of pulsed-field gel electrophoresis (PFGE).

RESULTS

Investigations of six situations where MRSA was identified in one or more animals in a household or veterinary facility were performed. MRSA was isolated from 8 animals (5 dogs and 3 cats) with clinical infections, 1 cat that was in contact with 2 infected cats and 14/88 (16%) of household contacts or veterinary personnel. Both animal-to-human and human-to-animal transmission were suspected. An indistinguishable MRSA isolate was recovered from at least one human that was in contact with each animal case. All isolates were classified as Canadian epidemic MRSA-2, the predominant community-associated MRSA clone in humans in Canada. No isolates possessed genes encoding for the PVL.

CONCLUSIONS

Transmission of MRSA between humans and animals, in both directions, was suspected. MRSA appears to be an emerging veterinary and zoonotic pathogen.

摘要

目的

描述耐甲氧西林金黄色葡萄球菌(MRSA)在家庭宠物中的感染和定植情况,以及MRSA在动物和人类之间的传播。

方法

在家庭宠物被鉴定为感染或定植MRSA后启动的调查中,评估家庭宠物及其人类接触者中的MRSA感染和定植情况,以确定动物和人类之间是否发生了传播。通过聚合酶链反应对所有MRSA分离株进行杀白细胞素(PVL)基因筛查,并使用脉冲场凝胶电泳(PFGE)确定分离株的相关性。

结果

对在家庭或兽医机构中一只或多只动物身上鉴定出MRSA的六种情况进行了调查。从8只患有临床感染的动物(5只狗和3只猫)、1只与2只感染猫接触的猫以及88名家庭接触者或兽医人员中的14人(16%)身上分离出了MRSA。怀疑存在动物到人的传播以及人到动物的传播。从与每例动物病例接触的至少一名人类身上分离出了难以区分的MRSA分离株。所有分离株均被归类为加拿大流行MRSA-2,这是加拿大人类中主要的社区相关MRSA克隆。没有分离株携带编码PVL的基因。

结论

怀疑MRSA在人和动物之间双向传播。MRSA似乎是一种新出现的兽医和人畜共患病原体。

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