Hartwig John H, Italiano Joseph E
Hematology Division, Brigham and Women's Hospital, 1 Blackfan Circle, Boston, MA 02115, USA.
Blood Cells Mol Dis. 2006 Mar-Apr;36(2):99-103. doi: 10.1016/j.bcmd.2005.12.007. Epub 2006 Feb 7.
Platelets release from megakaryocytes living primarily in the bone marrrow space. Intermediates in platelet formation are proplatelets, long tube-like processes that are extended by microtubule-based forces hundreds of micrometers from the megakaryocyte cell body. Granules and organelles enter the proplatelets and traffic up and down on their microtubules to be ultimately delivered to the platelet buds before they release. How individual platelets form and release from proplatelets remains poorly understood.
血小板由主要存在于骨髓空间的巨核细胞产生。血小板形成过程中的中间体是前血小板，即长管状突起，通过基于微管的力从巨核细胞体延伸数百微米。颗粒和细胞器进入前血小板，并在其微管上上下移动，最终在释放前被输送到血小板芽。单个血小板如何从前血小板形成并释放仍知之甚少。
