Tsujimoto Y
Osaka University Medical School, Biomedical Research Center, Suita, Osaka 565, Japan.
Cell Death Differ. 1997 Aug;4(6):429-34. doi: 10.1038/sj.cdd.4400262.
Apoptosis and necrosis are two distinct modes of cell death with respective morphological characteristics. However, apoptosis and some forms of necrosis must share common steps since both modes of cell death can be suppressed by the anti-apoptotic Bcl-2 protein and caspase inhibitors. Intracellular ATP levels have been implicated both in vitro and in vivo as a determinant of the cell's decision to die by apoptosis or necrosis.
凋亡和坏死是两种具有各自形态学特征的不同细胞死亡模式。然而，凋亡和某些形式的坏死必定有共同的步骤，因为这两种细胞死亡模式都可被抗凋亡的Bcl-2蛋白和半胱天冬酶抑制剂所抑制。细胞内ATP水平在体外和体内都被认为是决定细胞通过凋亡还是坏死途径死亡的一个因素。
