与艾氏枝霉细胞分化相关的环核苷酸代谢
Cyclic nucleotide metabolism coupled to cytodifferentiation of Blastocladiella emersonii.
作者信息
Silverman P M, Epstein P M
出版信息
Proc Natl Acad Sci U S A. 1975 Feb;72(2):442-6. doi: 10.1073/pnas.72.2.442.
Abstract
Cyclic GMP and cyclic AMP levels during growth and differentiation of B. emersonii were measured by use of chemical, biochemical, and immunologic assays. Of particular interest was the finding that net synthesis of cyclic GMP occurred during a single stage of its life cycle, sporulation, when intracellular levels increased 50- to 100-fold in a process requiring protein and RNA synthesis.
摘要
通过化学、生化和免疫分析方法，测定了埃默森布氏菌生长和分化过程中环状鸟苷单磷酸（cGMP）和环状腺苷单磷酸（cAMP）的水平。特别值得关注的是，研究发现cGMP的净合成发生在其生命周期的一个阶段——孢子形成期，在此过程中，细胞内cGMP水平在需要蛋白质和RNA合成的过程中增加了50至100倍。
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