Legat Franz J
Universitätsklinik für Dermatologie und Venerologie, Medizinische Universität Graz, Auenbruggerpl. 8, 8036, Graz, Österreich.
Hautarzt. 2018 Aug;69(8):631-640. doi: 10.1007/s00105-018-4229-z.
Phototherapy and photochemotherapy (PUVA) are important treatment modalities in inflammatory skin diseases such as psoriasis and atopic dermatitis as well as in cutaneous T‑cell lymphoma (e.g., mycosis fungoides/Sezary syndrome). Many of these skin diseases are accompanied by distracting pruritus. In addition, patients may suffer from intense pruritus in systemic diseases of the kidney and liver as well as of the endocrine and hematopoietic system. UV-light during phototherapy is capable of not only improving the inflammatory skin lesions but also of reducing the pruritus in skin and systemic diseases. The significant antipruritic effect, the usually low rate of well-known side effects, as well as the possibility to treat adults of any age, pregnant and lactating women, and under certain circumstances also children, make phototherapy a valuable treatment option for pruritus of various origin. Thus, the use of phototherapy should be considered early in the course of antipruritic therapy, when topical treatment modalities are insufficient to significantly improve pruritus.
光疗和光化学疗法（补骨脂素加紫外线A，PUVA）是治疗诸如银屑病和特应性皮炎等炎症性皮肤病以及皮肤T细胞淋巴瘤（如蕈样肉芽肿/塞扎里综合征）的重要治疗方式。这些皮肤病中有许多都伴有令人困扰的瘙痒。此外，患者在肾脏、肝脏以及内分泌和造血系统的全身性疾病中也可能会遭受剧烈瘙痒。光疗期间的紫外线不仅能够改善炎症性皮肤病变，还能减轻皮肤和全身性疾病中的瘙痒。显著的止痒效果、通常较低的已知副作用发生率，以及治疗任何年龄的成年人、孕妇和哺乳期妇女的可能性，在某些情况下还能治疗儿童，使得光疗成为治疗各种原因引起瘙痒的一种有价值的治疗选择。因此，当局部治疗方式不足以显著改善瘙痒时，应在止痒治疗过程中尽早考虑使用光疗。
