Kopytova F V
State Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow, Russia.
Neurosci Behav Physiol. 2006 Mar;36(3):227-33. doi: 10.1007/s11055-006-0004-1.
The neural mechanisms of the age-related characteristics of memory formation were studied in experiments based on a model providing an analog of a conditioned reflex to time: trace assimilation of the rhythm with which neurons in hippocampal field CA1 were stimulated, in rabbits aged 1-4 weeks and 5-6 months. Stages of changes in neuron spike activity characteristic for developing animals were described. In animals studied one week after birth, there was a predominance of silent cells and cells with low spontaneous activity. At 2-3 weeks of life, the level of spontaneous neuron activity increased, reaching adult levels by 25-30 days. The dynamics of the ontogenetic development of learning ability showed a number of stages: from virtually complete inability to form and assimilate traces of the rhythm (at age 6-7 days) to the stage of good formation and rapid forgetting (8-14 days), and, finally, the development of complete memory (25-30 days). The synchronous development of plastic rearrangements and the level of spontaneous neuron activity provided evidence of the direct involvement of the mechanisms underlying the formation of spontaneous spike activity in the organization of neural processes supporting adaptive reactions in the developing animal.
基于一种提供对时间的条件反射类似物的模型进行实验，研究了1至4周龄和5至6月龄兔子记忆形成的年龄相关特征的神经机制：海马体CA1区神经元受刺激节律的痕迹同化。描述了发育中动物神经元放电活动变化的阶段。在出生后一周研究的动物中，沉默细胞和自发活动低的细胞占主导。在2至3周龄时，神经元自发活动水平增加，到25至30天时达到成年水平。学习能力个体发育的动态显示出多个阶段：从几乎完全无法形成和同化节律痕迹（6至7日龄）到良好形成和快速遗忘阶段（8至14日龄），最后是完全记忆的发展（25至30日龄）。可塑性重排与神经元自发活动水平的同步发展证明，自发放电活动形成机制直接参与了支持发育中动物适应性反应的神经过程组织。
