Oxley Eric, Yang Chenglong, Liu Jian, Harrison W W
LECO Corporation, St. Joseph, Michigan 49085-2396, USA.
Anal Chem. 2003 Dec 1;75(23):6478-84. doi: 10.1021/ac0346398.
A Grimm-type glow discharge ion source, operated in the microsecond pulsed mode, has been interfaced to a commercial time-of-flight mass spectrometer. Ion transport from the source to the mass spectrometer, an inherent limitation of a Grimm source and mass spectrometer combination, was evaluated. The primary discharge operating conditions found to influence transport efficiency were gas flow rate and source pressure. The configuration of the Grimm-type source also influenced ion transport, including use of a gas-directing sleeve device. The effect of transport efficiency was separated into two components: (1) total ion signal and (2) temporal resolution. The latter is an advantage afforded by use of a pulsed glow discharge source and time-of-flight spectrometer, which allows discrimination against interfering gaseous background ions by appropriate ion sampling time. Shown as an example is the identification of trace magnesium from potential background interference using an optimized source configuration based on this temporal resolution method.
一种以微秒脉冲模式运行的格林姆型辉光放电离子源已与一台商用飞行时间质谱仪连接。对离子从离子源传输到质谱仪这一格林姆离子源与质谱仪组合的固有局限进行了评估。发现影响传输效率的主要放电操作条件是气体流速和离子源压力。格林姆型离子源的配置也影响离子传输，包括使用气体导向套筒装置。传输效率的影响被分为两个部分：（1）总离子信号和（2）时间分辨率。后者是使用脉冲辉光放电离子源和飞行时间光谱仪所带来的优势，它允许通过适当的离子采样时间来区分干扰性气态背景离子。作为示例展示了基于这种时间分辨率方法，使用优化的离子源配置从潜在背景干扰中识别痕量镁。
