Starcher B, James H
Department of Biochemistry, University of Texas Health Center, Tyler 75710.
Am Rev Respir Dis. 1991 Jun;143(6):1365-8. doi: 10.1164/ajrccm/143.6.1365.
Mutant tight-skin mice that had severe pulmonary emphysema were crossed with beige mice that contained neutrophils deficient in elastase activity. The resultant tight skin-beige cross mice were deficient in neutrophil elastase activity, yet they were still afflicted with the same degree of severe emphysema as the tight-skin mice. The results indicate that neutrophil elastase does not cause the emphysematous lesions found in tight-skin mice.
患有严重肺气肿的突变型紧皮小鼠与中性粒细胞弹性蛋白酶活性缺乏的米色小鼠杂交。产生的紧皮-米色杂交小鼠缺乏中性粒细胞弹性蛋白酶活性，但它们仍然患有与紧皮小鼠相同程度的严重肺气肿。结果表明，中性粒细胞弹性蛋白酶不会导致紧皮小鼠中发现的肺气肿病变。
