Shin J I, Park J M, Shin Y H, Hwang D H, Kim J H, Lee J S
Department of Paediatrics, The Institute of Kidney Disease, Yonsei University, College of Medicine, Seoul, Korea.
Scand J Rheumatol. 2006 Jan-Feb;35(1):56-60. doi: 10.1080/03009740510026841.
To identify predictive factors for nephritis, relapse, and significant proteinuria in childhood Henoch-Schönlein purpura (HSP).
Two hundred and six consecutive patients with HSP (93 female, 113 male), followed up at a single centre between 1996 and 2001, were analysed retrospectively. They were regularly monitored for clinical and laboratory parameters for renal sequelae and relapse.
Nephritis was seen in 78 patients (38%), relapse in 52 (25%), and significant proteinuria in 39 (19%). In univariate analysis, an older age at onset (>10 years), persistent purpura, severe bowel angina, and relapse were identified as factors associated with nephritis and significant proteinuria. Relapse-related factors were an older age, persistent purpura, severe bowel angina, and leucocytosis. Logistic regression analysis showed that nephritis was significantly associated with an older age, persistent purpura, and relapse, and significant proteinuria was closely related to severe bowel angina and relapse.
We identified some predictors for nephritis, relapse, and significant proteinuria in childhood HSP, and close attention should be paid to those patients with the risk factors, such as an older age at onset, persistent purpura, severe bowel angina, and relapse.
确定儿童过敏性紫癜（HSP）肾炎、复发及大量蛋白尿的预测因素。
回顾性分析1996年至2001年在单一中心随访的206例连续性HSP患者（93例女性，113例男性）。定期监测其肾脏后遗症及复发的临床和实验室参数。
78例患者（38%）出现肾炎，52例（25%）复发，39例（19%）出现大量蛋白尿。单因素分析显示，发病年龄较大（>10岁）、紫癜持续、严重肠绞痛及复发被确定为与肾炎和大量蛋白尿相关的因素。与复发相关的因素为年龄较大、紫癜持续、严重肠绞痛及白细胞增多。逻辑回归分析表明，肾炎与年龄较大、紫癜持续及复发显著相关，大量蛋白尿与严重肠绞痛及复发密切相关。
我们确定了儿童HSP肾炎、复发及大量蛋白尿的一些预测因素，对于有发病年龄较大、紫癜持续、严重肠绞痛及复发等危险因素的患者应密切关注。
