Poustie Vanessa J, Russell Jayne E, Watling Ruth M, Ashby Deborah, Smyth Rosalind L
University of Liverpool Division of Child Health, Royal Liverpool Children's Hospital, Liverpool L12 2AP.
BMJ. 2006 Mar 18;332(7542):632-6. doi: 10.1136/bmj.38737.600880.AE. Epub 2006 Feb 8.
To determine whether oral protein energy supplements, used long term in children with cystic fibrosis who are moderately malnourished, improve nutritional and other outcomes.
Multicentre randomised controlled trial.
Seven specialist paediatric cystic fibrosis centres and their associated shared care clinics and seven smaller paediatric cystic fibrosis clinics.
102 children with cystic fibrosis, aged between 2 and 15 years, who were moderately malnourished.
Oral protein energy supplements in addition to usual dietary advice compared with dietary advice alone, for 12 months.
Change in body mass index centile over one year.
Use of supplements was not associated with a change in body mass index centile (mean difference 2.99 centile points, 95% confidence interval -2.70 to 8.68) or other nutritional and spirometric outcomes in this group of children.
Long term use of oral protein energy supplements did not result in an improvement in nutritional status or other clinical outcomes in children with cystic fibrosis who were moderately malnourished. Oral protein energy supplements should not be regarded as an essential part of the management of this group of children.
ISRCTN: 95744468.
确定长期给中度营养不良的囊性纤维化患儿口服蛋白质能量补充剂是否能改善营养状况及其他结局。
多中心随机对照试验。
7家儿科囊性纤维化专科中心及其相关的共享护理诊所和7家规模较小的儿科囊性纤维化诊所。
102名年龄在2至15岁之间的中度营养不良的囊性纤维化患儿。
除常规饮食建议外，口服蛋白质能量补充剂，为期12个月，并与仅接受饮食建议进行比较。
一年内体重指数百分位的变化。
在这组儿童中，补充剂的使用与体重指数百分位的变化（平均差异2.99个百分位，95%置信区间为-2.70至8.68）或其他营养和肺功能检查结局无关。
长期口服蛋白质能量补充剂并未改善中度营养不良的囊性纤维化患儿的营养状况或其他临床结局。口服蛋白质能量补充剂不应被视为这组患儿治疗的必要组成部分。
ISRCTN：95744468。
