Laukkanen J A, Kurl S, Salonen J T, Lakka T A, Rauramaa R
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Heart. 2006 Sep;92(9):1219-24. doi: 10.1136/hrt.2005.077487. Epub 2006 Feb 8.
To investigate the prognostic value of peak oxygen pulse, which is the amount of oxygen consumed per heart beat during exercise, and to compare the prognostic value of peak oxygen pulse and maximum oxygen uptake (Vo(2max)) with respect to coronary heart disease (CHD) and overall death.
Prospective population-based study based on 1596 men without CHD or the use of beta blockers at baseline.
The risk of CHD was 2.45 (95% CI 1.10 to 5.45) times higher in men with low peak oxygen pulse (< 13.5 ml/beat) than in those with high peak oxygen pulse (> 17.8 ml/beat) after adjustment for age, alcohol consumption, smoking, body mass index, blood pressure, serum lipids, diabetes, family history of CHD and ischaemic ST changes during exercise. During an average follow up of 14 years, 267 men died, 67 of them due to CHD. The respective risk for overall death was 1.79 (95% CI 1.21 to 2.65). The continuous variable Vo(2max) was a stronger risk predictor than peak oxygen pulse for CHD and overall death.
Assessment of oxygen pulse provides no complementary information to Vo(2max) about cardiorespiratory fitness and prognosis for CHD. The analysis of respiratory gas exchange including the assessment of oxygen pulse during exercise does, however, provide an additional means for defining prognosis for patients with CHD.
研究峰值氧脉搏（即运动期间每次心跳所消耗的氧量）的预后价值，并比较峰值氧脉搏和最大摄氧量（Vo₂max）对冠心病（CHD）和全因死亡的预后价值。
基于1596名基线时无冠心病或未使用β受体阻滞剂的男性进行的前瞻性人群研究。
在校正年龄、饮酒量、吸烟、体重指数、血压、血脂、糖尿病、冠心病家族史以及运动期间缺血性ST段改变后，峰值氧脉搏低（<13.5毫升/次心跳）的男性患冠心病的风险比峰值氧脉搏高（>17.8毫升/次心跳）的男性高2.45倍（95%可信区间1.10至5.45）。在平均14年的随访期间，267名男性死亡，其中67人死于冠心病。全因死亡的相应风险为1.79（95%可信区间1.21至2.65）。对于冠心病和全因死亡，连续变量Vo₂max比峰值氧脉搏是更强的风险预测指标。
对于冠心病的心肺适能和预后，氧脉搏评估相对于Vo₂max并未提供补充信息。然而，包括运动期间氧脉搏评估在内的呼吸气体交换分析确实为确定冠心病患者的预后提供了额外手段。
