自发性高血压大鼠中钙通道的年龄相关变化

Age related changes in Ca2+ channels in spontaneously hypertensive rats.

Galletti F, Rutledge A, Krogh V, Triggle D J

Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo 14260.

Gen Pharmacol. 1991;22(1):173-6. doi: 10.1016/0306-3623(91)90330-9.

Abstract

The binding of the Ca2+ channel antagonist [3H]PN200 110 to 1,4-dihydropyridine binding sites in cardiac, brain and vascular smooth muscle preparations from WKY and SHR was studied as a function of age and blood pressure. 2. Binding site density in the heart from prehypertensive SHR (6 weeks) was significantly lower than that of WKY. 3. Between 6 and 12 weeks binding site density in SHR increased and between 12 and 24 weeks there was no difference between WKY and SHR. No changes in affinity occurred. 4. In brain a significant fall in binding site density occurred between 6 and 12 weeks and there was (with limited data) an increase in binding site density in tail artery membranes. 5. A good correlation (r = 0.82) exists between blood pressure and cardiac binding site density between 6 and 12 weeks of age in SHR.

摘要

研究了Ca2+通道拮抗剂[3H]PN200 110与WKY和SHR心脏、脑及血管平滑肌制剂中1,4 - 二氢吡啶结合位点的结合情况，作为年龄和血压的函数。2. 高血压前期SHR（6周龄）心脏中的结合位点密度显著低于WKY。3. 在6至12周龄期间，SHR的结合位点密度增加，在12至24周龄时，WKY和SHR之间没有差异。亲和力没有变化。4. 在脑中，6至12周龄期间结合位点密度显著下降，并且（数据有限）尾动脉膜中的结合位点密度增加。5. 在SHR 6至12周龄期间，血压与心脏结合位点密度之间存在良好的相关性（r = 0.82）。