Ganten D, Ganten U, Schelling P, Boucher R, Genest J
Proc Soc Exp Biol Med. 1975 Feb;148(2):568-72.
Renin, iso-renin, angiotensin I. angiotensin-converting enzyme, and angiotensinases were measured in plasma and in various extrarenal tissues of rats. Despite complete suppression of plasma renin in rats bearing pituitary tumors iso-renin and all other components of the renin-angiotensin system were found to be at or above control concentrations. The results strongly suggest that there is local synthesis of iso-renin in extrarenal tissues.
在大鼠的血浆和各种肾外组织中测量了肾素、同工肾素、血管紧张素I、血管紧张素转换酶和血管紧张素酶。尽管垂体肿瘤大鼠的血浆肾素被完全抑制，但仍发现同工肾素和肾素-血管紧张素系统的所有其他成分处于或高于对照浓度。结果强烈表明，肾外组织中存在同工肾素的局部合成。
