Breckow Joachim
Fachhochschule Giessen-Friedberg, Institut für Medizinische Physik und Strahlenschutz, Wiesenstr 14, 35390 Giessen, Germany.
Radiat Environ Biophys. 2006 Mar;44(4):257-60. doi: 10.1007/s00411-006-0030-y. Epub 2006 Feb 9.
The linear-no-threshold (LNT) controversy covers much more than the mere discussion whether or not "the LNT hypothesis is valid". It is shown that one cannot expect to find only one or even the only one dose-effect relationship. Each element within the biological reaction chain that is affected by ionizing radiation contributes in a specific way to the final biological endpoint of interest. The resulting dose-response relationship represents the superposition of all these effects. Till now there is neither a closed and clear picture of the entirety of radiation action for doses below some 10 mSv, nor does clear epidemiological evidence exist for an increase of risk for stochastic effects, in this dose range. On the other hand, radiation protection demands for quantitative risk estimates as well as for practicable dose concepts. In this respect, the LNT concept is preferred against any alternative concept. However, the LNT concept does not necessarily mean that the mechanism of cancer induction is intrinsically linear. It could hold even if the underlying multi-step mechanisms act in a non-linear way. In this case it would express a certain "attenuation" of non-linearities. Favouring LNT against threshold-, hyper-, or sub-linear models for radiation-protection purposes on the one hand, but preferring one of these models (e.g. for a specific effect) because of biological considerations for scientific purposes on the other hand, does not mean a contradiction.
线性无阈(LNT)争议所涵盖的内容远不止单纯讨论“LNT假说是否有效”。事实表明,人们不能期望仅找到一种甚至唯一的剂量效应关系。生物反应链中受电离辐射影响的每个元素都以特定方式对最终感兴趣的生物学终点产生影响。由此产生的剂量反应关系代表了所有这些效应的叠加。到目前为止,对于低于约10毫希沃特的剂量,既没有关于辐射作用整体的完整清晰图景,在这个剂量范围内也不存在明确的流行病学证据表明随机效应风险增加。另一方面,辐射防护需要定量的风险估计以及切实可行的剂量概念。在这方面,LNT概念比任何其他替代概念更受青睐。然而,LNT概念并不一定意味着癌症诱发机制本质上是线性的。即使潜在的多步骤机制以非线性方式起作用,它也可能成立。在这种情况下,它将表达某种非线性的“衰减”。一方面,出于辐射防护目的倾向于LNT而非阈值、超线性或亚线性模型,但另一方面,出于科学目的基于生物学考虑而倾向于这些模型中的某一个(例如针对特定效应),这并不矛盾。