Stelow Edward B, Mills Stacey E
Robert E. Fechner Laboratory of Surgical Pathology, Department of Pathology, University of Virginia, Charlottesville 22908, USA.
Am J Clin Pathol. 2005 Dec;124 Suppl:S96-109. doi: 10.1309/CR5JXUY3J2YGTC1D.
Squamous cell carcinoma (SCC) is by far the most common malignancy of the upper aerodigestive tract. Most conventional-type SCCs do not present the surgical pathologist with diagnostic difficulty. Certain variants, however, can histologically mimic benign and other malignant diseases. In such cases, correct diagnosis is important for prognostic and therapeutic reasons. This article discusses the clinicopathologic features of the upper aerodigestive tract variants of SCC, including verrucous carcinoma, papillary squamous cell carcinoma, basaloid squamous cell carcinoma, spindle cell carcinoma, adenosquamous carcinoma, adenoid squamous cell carcinoma, and undifferentiated carcinoma. It also discusses the differential diagnoses that must be considered and the use of ancillary testing, especially immunohistochemical analysis, for determining the correct diagnosis.
鳞状细胞癌（SCC）是目前上消化道最常见的恶性肿瘤。大多数传统类型的SCC对手术病理学家来说不存在诊断困难。然而，某些变异型在组织学上可模仿良性和其他恶性疾病。在这种情况下，出于预后和治疗原因，正确诊断很重要。本文讨论了SCC上消化道变异型的临床病理特征，包括疣状癌、乳头状鳞状细胞癌、基底样鳞状细胞癌、梭形细胞癌、腺鳞癌、腺样鳞状细胞癌和未分化癌。还讨论了必须考虑的鉴别诊断以及使用辅助检查，特别是免疫组化分析来确定正确诊断。
