Cipolla Calogero, Sandonato Luigi, Graceffa Giuseppa, Fricano Salvatore, Torcivia Adriana, Vieni Salvatore, Latteri Stefania, Latteri Mario Adelfio
University of Palermo, Department of Oncology, Division of General and Oncological Surgery Policlinico "P. Giaccone" Palermo, Italy.
Am Surg. 2005 Oct;71(10):874-8.
Several studies report a higher rate of papillary thyroid carcinomas (PTC) in patients with Hashimoto thyroiditis (HT), indicating a possible correlation between the two diseases. We studied a group of 89 subjects undergoing surgery for thyroid carcinomas compared with a control group of 89 subjects operated on for normofunctioning goiter, and a second group of 47 patients undergoing total thyroidectomy for HT. Association with HT was found in 19 of the 71 PTC subjects (26.7%) and in 8 goiter patients (8.9%), which was a significant difference (P < 0.02). Thirteen of the HT patients, mostly with the nodular form, showed coexistent PTC (27.6%). HT and PTC coexisted in several morphological, immunohistochemical, and biomolecular aspects; increased incidence of PTC in HT patients might therefore indicate that HT is a precursor of thyroid cancer. Further studies are required, however, in order to confirm this hypothesis; until then, HT patients should undergo careful clinical and technical follow-up.
多项研究报告称，桥本甲状腺炎（HT）患者的甲状腺乳头状癌（PTC）发生率较高，这表明两种疾病之间可能存在关联。我们研究了一组89例接受甲状腺癌手术的患者，并与一组89例因甲状腺功能正常的甲状腺肿而接受手术的对照组以及另一组47例因HT接受甲状腺全切除术的患者进行了比较。在71例PTC患者中有19例（26.7%）与HT有关联，在8例甲状腺肿患者中有8例（8.9%）与HT有关联，这是一个显著差异（P<0.02）。13例HT患者（大多为结节型）显示并存PTC（27.6%）。HT和PTC在多个形态学、免疫组织化学和生物分子方面并存；因此，HT患者中PTC发病率的增加可能表明HT是甲状腺癌的前驱病变。然而，需要进一步研究以证实这一假设；在此之前，HT患者应接受仔细的临床和技术随访。
