（-）-柄海鞘胺的形式全合成。
Formal total synthesis of (-)-lepadiformine.
作者信息
Lee Minhee, Lee Taeho, Kim Eun-Young, Ko Hyojin, Kim Deukjoon, Kim Sanghee
机构信息
College of Pharmacy, Seoul National University, San 56-1, Shilim, Kwanak, Seoul 151-742, Korea.
出版信息
Org Lett. 2006 Feb 16;8(4):745-8. doi: 10.1021/ol053010j.
PMID:16468757
Abstract
[reaction: see text] A stereocontrolled approach to the preparation of the Weinreb intermediate 3 has been developed. The important features of this approach are the creation of stereogenic centers through a cyclic amino acid ester-enolate Claisen rearrangement and the use of ring-closing metathesis for the construction of the azaspirocyclic skeleton.
摘要
[反应：见正文] 已开发出一种立体控制的方法来制备Weinreb中间体3。该方法的重要特征是通过环状氨基酸酯烯醇盐克莱森重排产生立体中心，并使用闭环复分解反应构建氮杂螺环骨架。
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