Inada K, Yamashita J, Yoshimura T, Matsuo S, Nakashima Y, Yamashita S, Misumi A, Ogawa M
Second Department of Surgery, Kumamoto University Medical School, Japan.
Jpn J Surg. 1991 Mar;21(2):249-52. doi: 10.1007/BF02470918.
Oophorectomy was found to decrease the plasminogen activator activity of rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA) to less than 7 per cent, while in vivo estradiol treatment restored its activity in a dose dependent fashion. The peroxidase activity was not changed either by oophorectomy or by the administration of estrogen. In the rat uterus, plasminogen activator activity was not changed by oophorectomy or by the administration of estrogen, however, its peroxidase activity decreased to less than 2 per cent following oophorectomy, while estrogen administration restored its activity. Estrogen regulated plasminogen activator activity in the DMBA-induced rat mammary tumors but not in the uterus and thus, the specific hormonal regulation of this enzyme may be an important factor for the hormonal dependent growth of such tumors.
研究发现，卵巢切除术可使7, 12-二甲基苯并(a)蒽（DMBA）诱导的大鼠乳腺肿瘤的纤溶酶原激活剂活性降至7%以下，而体内雌二醇治疗可使其活性以剂量依赖方式恢复。卵巢切除术或雌激素给药均未改变过氧化物酶活性。在大鼠子宫中，卵巢切除术或雌激素给药均未改变纤溶酶原激活剂活性，然而，卵巢切除术后其过氧化物酶活性降至2%以下，而雌激素给药可恢复其活性。雌激素调节DMBA诱导的大鼠乳腺肿瘤中的纤溶酶原激活剂活性，但不调节子宫中的活性，因此，该酶的特定激素调节可能是此类肿瘤激素依赖性生长的重要因素。
