Nishimura R, Kimura M, Tokunaga T, Akagi M
Gan. 1982 Oct;73(5):713-20.
Nuclear estrogen receptors (ERN) were measured in human breast cancer and 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma using the dextran-coated charcoal method without addition of an adsorbing material such as hydroxyapatite. Cytoplasmic estrogen receptors (ERC), cytoplasmic progesterone receptors (PgR), and ERN were measured in 111 primary and 11 locally recurrent breast cancers. ERC were found in 52%, PgR in 35%, and ERN in 40%. ERN and PgR were more frequent in tumors with a higher level of ERC. PgR were more frequent in ERN-positive tumors, and ERN were more frequent in PgR-positive tumors. The addition of an ERN assay to both ERC and PgR assay may be more informative for prediction of estrogen dependency than the mere determination of the existence of receptors in the cytoplasm.
采用葡聚糖包被活性炭法，在不添加诸如羟基磷灰石等吸附材料的情况下，对人乳腺癌及7,12 - 二甲基苯并[a]蒽诱导的乳腺癌中的核雌激素受体（ERN）进行了检测。对111例原发性和11例局部复发性乳腺癌进行了细胞质雌激素受体（ERC）、细胞质孕激素受体（PgR）及ERN的检测。发现52%的肿瘤存在ERC，35%存在PgR，40%存在ERN。在ERC水平较高的肿瘤中，ERN和PgR更为常见。在ERN阳性肿瘤中PgR更为常见，而在PgR阳性肿瘤中ERN更为常见。相较于单纯检测细胞质中受体的存在情况，将ERN检测与ERC和PgR检测相结合，对于预测雌激素依赖性可能更具信息价值。
